Intracellular ESAT-6: A new biomarker forMycobacterium tuberculosisinfection

Introducing the ESAT-6 free IGRA, a companion diagnostic for TB vaccines based on ESAT-6

There is a need for an improved vaccine for tuberculosis. ESAT-6 is a cardinal vaccine antigen with unique properties and is included in several vaccine candidates in development. ESAT-6 is also the core antigen in the IFN-γ release assays (IGRA) used to diagnose latent infection, rendering IGRA tests unspecific after vaccination. This challenge has prompted the development of a companion diagn...

ESAT-6 subunit vaccination against Mycobacterium tuberculosis.

The ESAT-6 antigen from Mycobacterium tuberculosis is a dominant target for cell-mediated immunity in the early phase of tuberculosis (TB) in TB patients as well as in various animal models. The purpose of our study was to evaluate the potential of ESAT-6 in an experimental TB vaccine. We started out using dimethyl dioctadecylammonium bromide (DDA), an adjuvant which has been demonstrated to be...

Early Diagnosis of Tuberculosis-Associated IgA Nephropathy with ESAT-6.

IgA nephropathy (IgAN) is the most common cause of primary renal diseases worldwide, and the early secreted antigenic target of 6 (ESAT-6) which was secreted by Mycobacterium tuberculosis (MTB) may be involved in the development and progression of IgAN. This study aimed to investigate the role of ESAT-6 for early diagnosis of IgAN caused by MTB infection. From 2011 to 2014, 21 patients with ren...

ESAT-6 and CFP-10: what is the diagnosis?

Esat-6 as an Effective Mycobacterium Tuberculosis Subunit Vaccine

Tuberculosis is still one of the important infectious diseases and a major cause for public health problems, particularly in lowand middle-income countries. Prevention of this disease is a priority of WHO. Many antigens have been candidate for vaccination. Evaluating the safety and efficacy of these antigens is the concern of many researchers. This review is about ESAT-6 as an effective Mycobac...